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Search Results for " folate receptor α "

Targets Recommended: Antifolate

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76766	Mirvetuximab M9346A	Antifolate	Cell Cycle/Checkpoint
	Mirvetuximab (M9346A) 是一种新型叶酸受体α (FRα) 靶向 anti-FOLR1 (folate receptor 1) 的单克隆抗体。Mirvetuximab soravtansine 常与铂类化合物或与其他化合物偶联成为抗体-药物偶联物用来治疗卵巢癌和其他 FRα 阳性的癌症。
T76720	Farletuzumab MORAb-003	Antifolate	Cell Cycle/Checkpoint
	Farletuzumab (MORAb-003) 是一种有效的叶酸受体-α (FRα) 抑制剂。Farletuzumab 是一种对 FRα 具有高亲和力的人源化单克隆抗体。Farletuzumab 抑制过表达 FRα 的细胞的生长。Farletuzumab 可用于研究癌症。
T38490	ONX 0801 trisodium Idetrexedtrisodium,BGC 945 trisodium,CB300945trisodium
	ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.
T12635L	Plevitrexed BGC9331,ZD 9331	Others	Others
	Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is an orally active and effective thymidylate synthase (TS) inhibitor (Ki: 0.44 nM). Plevitrexed is used for gastric cancer in clinical.
T69268	BGC-638
	BGC-638, an analogue of BGC-945, is a thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)Â–overexpressing tumors.
T77908	Farletuzumab ecteribulin MORAb-202
	Farletuzumabecteribulin（MORAb-202）是一款人源化抗人叶酸受体α（FRA）抗体Farletuzumab与Mal-PEG2-Val-Cit-PAB-eribulin通过还原的链间二硫键偶联成的抗体-活性分子偶联物（ADC）。该化合物活性分子抗体比率为4.0，对FRA阳性细胞展示出强大的体外细胞毒性，并具备有效的抗肿瘤活性。

化合物

Mirvetuximab

Cat.No: T76766

Synonym: M9346A

Target: Antifolate

Farletuzumab

Cat.No: T76720

Synonym: MORAb-003

Target: Antifolate

ONX 0801 trisodium

Cat.No: T38490

Synonym: Idetrexedtrisodium,BGC 945 trisodium,CB300945trisodium

Target:

Plevitrexed

Cat.No: T12635L

Synonym: BGC9331,ZD 9331

Farletuzumab ecteribulin

Cat.No: T77908

Synonym: MORAb-202

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00147	FOLR1 Protein, Human, Recombinant (hFc) Folate receptor 1,Folate rece...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328.
TMPJ-00148	FOLR1 Protein, Rhesus macaque, Recombinant (His) FR-alpha,Adult folate-binding protein,Ovarian tumor...	Rhesus	HEK293 Cells
	FOLR1 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-38 kDa and the accession number is F7BP60.
TMPK-00150	FOLR1 Protein, Human, Recombinant (His & Avi) Folate receptor 1,Folbp1,Folate <...	Human	HEK293 Cells
	Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into t...